RAF Typhoon FGR4s have joined forces with France's air force in a combined operation on an underground arms cache in Syrian territory operated by the IS group, per a report from the UK Ministry of Defence.
The facility, identified by surveillance, was assessed as storing arms and explosives, the statement said, and was positioned in mountainous terrain just north of the ancient city of Palmyra in central Syria.
"Our aircraft utilized precision-guided Paveway IV munitions to hit a several entry passages leading to the facility... early reports are that the target was engaged successfully," the MoD said.
There was no evidence of any civilian impact in the strike on Saturday evening and every plane involved made a safe return, the MoD added.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
Daesh - referred to as Daesh - imposed militant control over large swathes of both Syria and Iraq until 2019.
"This strike demonstrates the UK's leading role, and commitment to operate in unison with our partners, to stamp out any revival of IS and their violent and radical beliefs in the Middle East," UK Defence Secretary John Healey remarked.
British military aircraft have conducted overwatch operations over Syrian airspace to "prevent any attempted comeback" of the group following its defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I extend gratitude to all the members of the UK armed forces who took part in this mission for their expertise and their courage," the Defence Secretary said. "They were among numerous British personnel on duty over the festive period. This action, to eliminate dangerous terrorists who endanger our safety, shows how British military are always on standby, throughout the year, ensuring Britain's security within its borders and powerful internationally."
During December, the United States armed forces carried out what it called a "large-scale strike" against Daesh sites in Syria, subsequent to an attack claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The U.N. estimates Daesh still has roughly 5-7 thousand fighters in Syria and Iraq.